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Dr. Barry Eppley

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The Promise of Reloxin for Facial Wrinkles

While Botox has long been in a battle with fighting wrinkles, it will soon be facing a new challenge….competition. Since Botox’s formal Food and Drug Administration (FDA) approval for its use in cosmetic facial applications (it had been used off-label for more than a decade before that), it has been unrivaled racking up sales close to $1 billion annually.

Within the next few months (April 13, 2009), the FDA is expected to approve a new injectable cosmetic wrinkle treatment known under the tradename Reloxin. Made from the same neurotoxin as Botox (botulinum toxin of type A), Reloxin is touted to act more quickly and perhaps somewhat longer than Botox. The U.S. distribution rights of Reloxin are owned by the Medicis company, who currently sells the popular injectable filler Restylane.

Reloxin is currently used around the world under different names such as Dysport and Azzalure. It is a neuromuscular blocking toxin and was initially developed for the treatment of motor disorders and various forms of muscular spasticity, including cervical dystonia, spasticity of the lower limbs in children with cerebral palsy, blepharospasm (involuntary eye closure) and hemifacial spasm. It was later developed for the treatment of a wide variety of neuromuscular disorders and aesthetic facial treatments. Since its use has been expanded to aesthetic medicine, it is approved in 23 countries: Argentina, Australia, Belarus, Brazil, Columbia, Ecuador, Egypt, El Salvador, Germany, Honduras, Israel, Kazakhstan, Mexico, Moldova, New Zealand, Philippines, Slovak Republic, South Korea, Ukraine, Uruguay, Venezuela, Vietnam, and Russia.

While the differences between Botox and Reloxin will no doubt be heavily debated in major marketing battles yet to come, the bottom line to patients is that we may see lower prices for these treatments. At worst, the prices will be the same, but I doubt it. The competition and incentives to get physicians to use them will unquestionably drive per treatment prices down. In most every other country in the world where both Botox and Dysport/Reloxin co-exist, the market is fairly evenly split between the two. I would expect to see the same phenomenon here in the U.S. within the next few years.

The difference between Reloxin and Botox, according to clinical trial reports from the manufacturer, is that Reloxin will act in one to two days instead of the three to five days that is needed for Botox. I am not sure that is such a significant advantage but early onset action is a value added benefit. The far more important benefit would be a longer duration of action. It is suggested that Reloxin may last as long as five or six months, compared to three or four months for Botox. If consistently effective and reproducible for the majority of patients, this would be a significant difference that would have widespread patient appeal.


Is Reloxin hype or hope? We’ll know by this time next year.

Dr. Barry Eppley

Indianapolis, Indiana

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Dr. Barry EppleyDr. Barry Eppley

Dr. Barry Eppley is an extensively trained plastic and cosmetic surgeon with more than 20 years of surgical experience. He is both a licensed physician and dentist as well as double board-certified in both Plastic and Reconstructive Surgery and Oral and Maxillofacial Surgery. This training allows him to perform the most complex surgical procedures from cosmetic changes to the face and body to craniofacial surgery. Dr. Eppley has made extensive contributions to plastic surgery starting with the development of several advanced surgical techniques. He is a revered author, lecturer and educator in the field of plastic and cosmetic surgery.

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